BCL10 FISH Probe
The BCL10 FISH probe is designed to hybridize to the BCL10 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCL10-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BCL10-20-RE | 20 (40 μL) | 200 μL |  |
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| BCL10-20-GO | 20 (40 μL) | 200 μL |  |
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| BCL10-20-GR | 20 (40 μL) | 200 μL |  |
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| BCL10-20-AQ | 20 (40 μL) | 200 μL |  |
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| BCL10-20-DIG | 20 (40 μL) | 200 μL |  |
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| BCL10-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Details
Gene Symbol: BCL10
Gene Name: B-cell CLL/lymphoma 10
Chromosome: CHR1: 85731459-85742587
Locus: 1p22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BCL10 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BCL10-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping