BARD1 FISH Probe
The BARD1 FISH probe is designed to hybridize to the BARD1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BARD1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BARD1-20-RE | 20 (40 μL) | 200 μL |  |
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| BARD1-20-GO | 20 (40 μL) | 200 μL |  |
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| BARD1-20-GR | 20 (40 μL) | 200 μL |  |
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| BARD1-20-AQ | 20 (40 μL) | 200 μL |  |
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| BARD1-20-DIG | 20 (40 μL) | 200 μL |  |
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| BARD1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Details
Gene Symbol: BARD1
Gene Name: BRCA1 Associated RING Domain 1
Chromosome: CHR2: 215593274-215674428
Locus: 2q35
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BARD1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BARD1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping