B-RAF1 FISH Probe
The B-RAF1 FISH probe is designed to hybridize to the B-RAF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BRAF-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BRAF-20-RE | 20 (40 μL) | 200 μL |  |
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| BRAF-20-GO | 20 (40 μL) | 200 μL |  |
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| BRAF-20-GR | 20 (40 μL) | 200 μL |  |
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| BRAF-20-AQ | 20 (40 μL) | 200 μL |  |
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| BRAF-20-DIG | 20 (40 μL) | 200 μL |  |
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| BRAF-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: BRAF
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812-140624564
Locus: 7q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: B-RAF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BRAF-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping