AZ-2 FISH Probe
The AZ-2 FISH probe is designed to hybridize to the AZ-2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OAZ2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-RE | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-GO | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-GR | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-AQ | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-DIG | 20 (40 μL) | 200 μL |  |
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| OAZ2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Gene Details
Gene Symbol: OAZ2
Gene Name: Ornithine Decarboxylase Antizyme 2
Chromosome: CHR15: 64979772-64995462
Locus: 15q22.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AZ-2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: OAZ2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping