AXIN2 FISH Probe
The AXIN2 FISH probe is designed to hybridize to the AXIN2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AXIN2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-RE | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-GO | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-GR | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-AQ | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-DIG | 20 (40 μL) | 200 μL |  |
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| AXIN2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: AXIN2
Gene Name: Axin 2
Chromosome: CHR17: 63524682-63557740
Locus: 17q24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AXIN2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: AXIN2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping