AVPR V2 FISH Probe
The AVPR V2 FISH probe is designed to hybridize to the AVPR V2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AVPR2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-RE | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-GO | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-GR | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-AQ | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-DIG | 20 (40 μL) | 200 μL |  |
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| AVPR2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: AVPR2
Gene Name: Arginine Vasopressin Receptor 2
Chromosome: CHRX: 153167984-153172620
Locus: Xq28
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AVPR V2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: AVPR2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping