ATXN8 FISH Probe
The ATXN8 FISH probe is designed to hybridize to the ATXN8 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TWNK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TWNK-20-RE | 20 (40 μL) | 200 μL |  |
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| TWNK-20-GO | 20 (40 μL) | 200 μL |  |
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| TWNK-20-GR | 20 (40 μL) | 200 μL |  |
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| TWNK-20-AQ | 20 (40 μL) | 200 μL |  |
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| TWNK-20-DIG | 20 (40 μL) | 200 μL |  |
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| TWNK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]
Gene Details
Gene Symbol: TWNK
Gene Name: Twinkle MtDNA Helicase
Chromosome: CHR10: 100987526-100994402
Locus: 10q24.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ATXN8 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TWNK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping