ATXN7 Break Apart FISH Probe
Empire Genomics’ ATXN7 Break Apart FISH Probe is designed to flank the ATXN7 gene and is typically used for detecting ATXN7 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATXN7BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-AQOR | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-GORE | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-GROR | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-REGO | 20 (40 μL) | 200 μL |
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| ATXN7BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: ATXN7
Gene Name: Ataxin 7
Chromosome: CHR3: 63850232-63989136
Locus: 3p14.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ATXN7 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ATXN7-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping