ATF6 Break Apart FISH Probe
Empire Genomics’ ATF6 Break Apart FISH Probe is designed to flank the ATF6 gene and is typically used for detecting ATF6 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATF6BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATF6BA-20-AQOR | 20 (40 μL) | 200 μL |
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| ATF6BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ATF6BA-20-GORE | 20 (40 μL) | 200 μL |
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| ATF6BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ATF6BA-20-GROR | 20 (40 μL) | 200 μL |
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| ATF6BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ATF6BA-20-REGO | 20 (40 μL) | 200 μL |
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| ATF6BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: ATF6
Gene Name: Activating Transcription Factor 6
Chromosome: CHR1: 161736033-161933860
Locus: 1q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ATF6 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ATF6-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping