ASK-1 FISH Probe
The ASK-1 FISH probe is designed to hybridize to the ASK-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP3K5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-AQ | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-DIG | 20 (40 μL) | 200 μL |  |
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| MAP3K5-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MAP3K5
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 5
Chromosome: CHR6: 136878186-137113656
Locus: 6q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ASK-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MAP3K5-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping