ASAH3 FISH Probe
The ASAH3 FISH probe is designed to hybridize to the ASAH3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACER1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ACER1-20-RE | 20 (40 μL) | 200 μL |  |
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| ACER1-20-GO | 20 (40 μL) | 200 μL |  |
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| ACER1-20-GR | 20 (40 μL) | 200 μL |  |
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| ACER1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ACER1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ACER1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Gene Details
Gene Symbol: ACER1
Gene Name: Alkaline Ceramidase 1
Chromosome: CHR19: 6306509-6333640
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ASAH3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACER1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping