AR FISH Probe
The AR FISH probe is designed to hybridize to the AR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| AR-20-RE | 20 (40 μL) | 200 μL |  |
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| AR-20-GO | 20 (40 μL) | 200 μL |  |
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| AR-20-GR | 20 (40 μL) | 200 μL |  |
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| AR-20-AQ | 20 (40 μL) | 200 μL |  |
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| AR-20-DIG | 20 (40 μL) | 200 μL |  |
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| AR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Details
Gene Symbol: AR
Gene Name: Androgen Receptor
Chromosome: CHRX: 66763873-66944119
Locus: Xq12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: AR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping