APR FISH Probe
The APR FISH probe is designed to hybridize to the APR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LRP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| LRP1-20-RE | 20 (40 μL) | 200 μL |  |
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| LRP1-20-GO | 20 (40 μL) | 200 μL |  |
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| LRP1-20-GR | 20 (40 μL) | 200 μL |  |
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| LRP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| LRP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| LRP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Details
Gene Symbol: LRP1
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281-57607125
Locus: 12q13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LRP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping