APPL2 Break Apart FISH Probe
Empire Genomics’ APPL2 Break Apart FISH Probe is designed to flank the APPL2 gene and is typically used for detecting APPL2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APPL2BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| APPL2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| APPL2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| APPL2BA-20-GORE | 20 (40 μL) | 200 μL |
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| APPL2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| APPL2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| APPL2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| APPL2BA-20-REGO | 20 (40 μL) | 200 μL |
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| APPL2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Gene Details
Gene Symbol: APPL2
Gene Name: Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2
Chromosome: CHR12: 105567074-105630008
Locus: 12q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APPL2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APPL2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping