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APP FISH Probe

The APP FISH probe is designed to hybridize to the APP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
APP-20-OR  (Standard Design) 20 (40 μL) 200 μL
APP-20-RE 20 (40 μL) 200 μL
APP-20-GO 20 (40 μL) 200 μL
APP-20-GR 20 (40 μL) 200 μL
APP-20-AQ 20 (40 μL) 200 μL
APP-20-DIG 20 (40 μL) 200 μL
APP-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Gene Details

Gene Symbol: APP

Gene Name: Amyloid Beta Precursor Protein

Chromosome: CHR21: 27252860-27543446

Locus: 21q21.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: APP FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: APP-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping