APO-1 FISH Probe
The APO-1 FISH probe is designed to hybridize to the APO-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FAS-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FAS-20-RE | 20 (40 μL) | 200 μL |  |
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| FAS-20-GO | 20 (40 μL) | 200 μL |  |
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| FAS-20-GR | 20 (40 μL) | 200 μL |  |
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| FAS-20-AQ | 20 (40 μL) | 200 μL |  |
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| FAS-20-DIG | 20 (40 μL) | 200 μL |  |
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| FAS-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Gene Details
Gene Symbol: FAS
Gene Name: Fas Cell Surface Death Receptor
Chromosome: CHR10: 90750287-90775542
Locus: 10q23.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APO-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FAS-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping