APH-1 FISH Probe
The APH-1 FISH probe is designed to hybridize to the APH-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APH1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APH1A-20-RE | 20 (40 μL) | 200 μL |  |
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| APH1A-20-GO | 20 (40 μL) | 200 μL |  |
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| APH1A-20-GR | 20 (40 μL) | 200 μL |  |
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| APH1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| APH1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| APH1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: APH1A
Gene Name: Aph-1 Homolog A, Gamma-secretase Subunit
Chromosome: CHR1: 150237798-150241609
Locus: 1q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APH-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APH1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping