APCL FISH Probe
The APCL FISH probe is designed to hybridize to the APCL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APC2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APC2-20-RE | 20 (40 μL) | 200 μL |  |
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| APC2-20-GO | 20 (40 μL) | 200 μL |  |
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| APC2-20-GR | 20 (40 μL) | 200 μL |  |
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| APC2-20-AQ | 20 (40 μL) | 200 μL |  |
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| APC2-20-DIG | 20 (40 μL) | 200 μL |  |
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| APC2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Gene Details
Gene Symbol: APC2
Gene Name: APC2, WNT Signaling Pathway Regulator
Chromosome: CHR19: 1450147-1473243
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APCL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APC2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping