APC2 Break Apart FISH Probe
Empire Genomics’ APC2 Break Apart FISH Probe is designed to flank the APC2 gene and is typically used for detecting APC2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APC2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| APC2BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Gene Details
Gene Symbol: APC2
Gene Name: APC2, WNT Signaling Pathway Regulator
Chromosome: CHR19: 1450147-1473243
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: APC2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APC2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping