APAF1 FISH Probe
The APAF1 FISH probe is designed to hybridize to the APAF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APAF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APAF1-20-RE | 20 (40 μL) | 200 μL |  |
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| APAF1-20-GO | 20 (40 μL) | 200 μL |  |
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| APAF1-20-GR | 20 (40 μL) | 200 μL |  |
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| APAF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| APAF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| APAF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: APAF1
Gene Name: Apoptotic Peptidase Activating Factor 1
Chromosome: CHR12: 99039077-99129211
Locus: 12q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APAF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APAF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping