APAA FISH Probe
The APAA FISH probe is designed to hybridize to the APAA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NAGPA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-RE | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-GO | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-GR | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-AQ | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-DIG | 20 (40 μL) | 200 μL |  |
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| NAGPA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015]
Gene Details
Gene Symbol: NAGPA
Gene Name: N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase
Chromosome: CHR16: 5074844-5083942
Locus: 16p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APAA FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NAGPA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping