ANK1 FISH Probe
The ANK1 FISH probe is designed to hybridize to the ANK1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ANK1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ANK1-20-RE | 20 (40 μL) | 200 μL |  |
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| ANK1-20-GO | 20 (40 μL) | 200 μL |  |
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| ANK1-20-GR | 20 (40 μL) | 200 μL |  |
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| ANK1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ANK1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ANK1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Gene Details
Gene Symbol: ANK1
Gene Name: Ankyrin 1
Chromosome: CHR8: 41510743-41754280
Locus: 8p11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ANK1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ANK1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping