AML1T1 FISH Probe
The AML1T1 FISH probe is designed to hybridize to the AML1T1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RUNX1T1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-RE | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-GO | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-GR | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-AQ | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-DIG | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Details
Gene Symbol: RUNX1T1
Gene Name: RUNX1 Translocation Partner 1
Chromosome: CHR8: 92967194-93115454
Locus: 8q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AML1T1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RUNX1T1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping