AKT FISH Probe
The AKT FISH probe is designed to hybridize to the AKT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AKT1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| AKT1-20-RE | 20 (40 μL) | 200 μL |  |
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| AKT1-20-GO | 20 (40 μL) | 200 μL |  |
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| AKT1-20-GR | 20 (40 μL) | 200 μL |  |
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| AKT1-20-AQ | 20 (40 μL) | 200 μL |  |
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| AKT1-20-DIG | 20 (40 μL) | 200 μL |  |
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| AKT1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Details
Gene Symbol: AKT1
Gene Name: AKT Serine/threonine Kinase 1
Chromosome: CHR14: 105235686-105262080
Locus: 14q32.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AKT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: AKT1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping