ADIR2 FISH Probe
The ADIR2 FISH probe is designed to hybridize to the ADIR2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NUP98-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NUP98-20-RE | 20 (40 μL) | 200 μL |  |
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| NUP98-20-GO | 20 (40 μL) | 200 μL |  |
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| NUP98-20-GR | 20 (40 μL) | 200 μL |  |
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| NUP98-20-AQ | 20 (40 μL) | 200 μL |  |
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| NUP98-20-DIG | 20 (40 μL) | 200 μL |  |
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| NUP98-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: NUP98
Gene Name: Nucleoporin 98
Chromosome: CHR11: 3696239-3819022
Locus: 11p15.4
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ADIR2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NUP98-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping