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ADD2 FISH Probe

The ADD2 FISH probe is designed to hybridize to the ADD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
ADD2-20-OR  (Standard Design) 20 (40 μL) 200 μL
ADD2-20-RE 20 (40 μL) 200 μL
ADD2-20-GO 20 (40 μL) 200 μL
ADD2-20-GR 20 (40 μL) 200 μL
ADD2-20-AQ 20 (40 μL) 200 μL
ADD2-20-DIG 20 (40 μL) 200 μL
ADD2-20-BIO 20 (40 μL) 200 μL

Gene Summary

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Gene Details

Gene Symbol: ADD2

Gene Name: Adducin 2

Chromosome: CHR2: 70889215-70995375

Locus: 2p13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: ADD2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ADD2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping