ADAMTS-4 FISH Probe
The ADAMTS-4 FISH probe is designed to hybridize to the ADAMTS-4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAMTS4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-RE | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-GO | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-GR | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-AQ | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-DIG | 20 (40 μL) | 200 μL |  |
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| ADAMTS4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: ADAMTS4
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4
Chromosome: CHR1: 161159537-161168845
Locus: 1q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ADAMTS-4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ADAMTS4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping