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ADAM17 FISH Probe

The ADAM17 FISH probe is designed to hybridize to the ADAM17 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
ADAM17-20-OR  (Standard Design) 20 (40 μL) 200 μL
ADAM17-20-RE 20 (40 μL) 200 μL
ADAM17-20-GO 20 (40 μL) 200 μL
ADAM17-20-GR 20 (40 μL) 200 μL
ADAM17-20-AQ 20 (40 μL) 200 μL
ADAM17-20-DIG 20 (40 μL) 200 μL
ADAM17-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]

Gene Details

Gene Symbol: ADAM17

Gene Name: ADAM Metallopeptidase Domain 17

Chromosome: CHR2: 9629410-9695917

Locus: 2p25.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: ADAM17 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ADAM17-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping