ACY-1B FISH Probe
The ACY-1B FISH probe is designed to hybridize to the ACY-1B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACY1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ACY1-20-RE | 20 (40 μL) | 200 μL |  |
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| ACY1-20-GO | 20 (40 μL) | 200 μL |  |
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| ACY1-20-GR | 20 (40 μL) | 200 μL |  |
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| ACY1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ACY1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ACY1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
Gene Details
Gene Symbol: ACY1
Gene Name: Aminoacylase 1
Chromosome: CHR3: 52017299-52023218
Locus: 3p21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ACY-1B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACY1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping