ACVR2B FISH Probe
The ACVR2B FISH probe is designed to hybridize to the ACVR2B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACVR2B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-RE | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-GO | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-GR | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-AQ | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-DIG | 20 (40 μL) | 200 μL |  |
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| ACVR2B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ACVR2B
Gene Name: Activin A Receptor Type 2B
Chromosome: CHR3: 38495789-38534633
Locus: 3p22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ACVR2B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACVR2B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping