SEARCH OUR PRODUCT CATALOG

As of March 8th, Empire is operating as an essential New York State business and has no production or shipping delays

ACO1 Break Apart FISH Probe

Empire Genomics’ ACO1 Break Apart FISH Probe is designed to flank the ACO1 gene and is typically used for detecting ACO1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
ACO1BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ACO1BA-20-AQOR 20 (40 μL) 200 μL
ACO1BA-20-GOGR 20 (40 μL) 200 μL
ACO1BA-20-GORE 20 (40 μL) 200 μL
ACO1BA-20-GRGO 20 (40 μL) 200 μL
ACO1BA-20-GROR 20 (40 μL) 200 μL
ACO1BA-20-GRRE 20 (40 μL) 200 μL
ACO1BA-20-REGO 20 (40 μL) 200 μL
ACO1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Gene Details

Gene Symbol: ACO1

Gene Name: Aconitase 1

Chromosome: CHR9: 32384600-32450832

Locus: 9p21.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: ACO1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ACO1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping