ACER1 Break Apart FISH Probe
Empire Genomics’ ACER1 Break Apart FISH Probe is designed to flank the ACER1 gene and is typically used for detecting ACER1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACER1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACER1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| ACER1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ACER1BA-20-GORE | 20 (40 μL) | 200 μL |
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| ACER1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ACER1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ACER1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| ACER1BA-20-REGO | 20 (40 μL) | 200 μL |
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| ACER1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Gene Details
Gene Symbol: ACER1
Gene Name: Alkaline Ceramidase 1
Chromosome: CHR19: 6306509-6333640
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ACER1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACER1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping