ABL1 FISH Probe
The ABL1 FISH probe is designed to hybridize to the ABL1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ABL1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ABL1-20-RE | 20 (40 μL) | 200 μL |  |
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| ABL1-20-GO | 20 (40 μL) | 200 μL |  |
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| ABL1-20-GR | 20 (40 μL) | 200 μL |  |
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| ABL1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ABL1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ABL1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Details
Gene Symbol: ABL1
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267-133763062
Locus: 9q34.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ABL1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ABL1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping