ABCB1 FISH Probe
The ABCB1 FISH probe is designed to hybridize to the ABCB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ABCB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-RE | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-GO | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-GR | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| ABCB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Details
Gene Symbol: ABCB1
Gene Name: ATP Binding Cassette Subfamily B Member 1
Chromosome: CHR7: 87133178-87342639
Locus: 7q21.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: ABCB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ABCB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping