A2M Break Apart FISH Probe
Empire Genomics’ A2M Break Apart FISH Probe is designed to flank the A2M gene and is typically used for detecting A2M rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| A2MBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| A2MBA-20-AQOR | 20 (40 μL) | 200 μL |
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| A2MBA-20-GOGR | 20 (40 μL) | 200 μL |
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| A2MBA-20-GORE | 20 (40 μL) | 200 μL |
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| A2MBA-20-GRGO | 20 (40 μL) | 200 μL |
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| A2MBA-20-GRRE | 20 (40 μL) | 200 μL |
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| A2MBA-20-ORGR | 20 (40 μL) | 200 μL |
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| A2MBA-20-REGO | 20 (40 μL) | 200 μL |
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| A2MBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Details
Gene Symbol: A2M
Gene Name: Alpha-2-macroglobulin
Chromosome: CHR12: 9220303-9268558
Locus: 12p13.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: A2M FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: A2M-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping