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A2M Break Apart FISH Probe

Empire Genomics’ A2M Break Apart FISH Probe is designed to flank the A2M gene and is typically used for detecting A2M rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
A2MBA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
A2MBA-20-AQOR 20 (40 μL) 200 μL
A2MBA-20-GOGR 20 (40 μL) 200 μL
A2MBA-20-GORE 20 (40 μL) 200 μL
A2MBA-20-GRGO 20 (40 μL) 200 μL
A2MBA-20-GRRE 20 (40 μL) 200 μL
A2MBA-20-ORGR 20 (40 μL) 200 μL
A2MBA-20-REGO 20 (40 μL) 200 μL
A2MBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Gene Details

Gene Symbol: A2M

Gene Name: Alpha-2-macroglobulin

Chromosome: CHR12: 9220303-9268558

Locus: 12p13.31

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: A2M FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: A2M-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping