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A2M FISH Probe

The A2M FISH probe is designed to hybridize to the A2M gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
A2M-20-OR  (Standard Design) 20 (40 μL) 200 μL
A2M-20-RE 20 (40 μL) 200 μL
A2M-20-GO 20 (40 μL) 200 μL
A2M-20-GR 20 (40 μL) 200 μL
A2M-20-AQ 20 (40 μL) 200 μL
A2M-20-DIG 20 (40 μL) 200 μL
A2M-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Gene Details

Gene Symbol: A2M

Gene Name: Alpha-2-macroglobulin

Chromosome: CHR12: 9220303-9268558

Locus: 12p13.31

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: A2M FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: A2M-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping