A2M FISH Probe
The A2M FISH probe is designed to hybridize to the A2M gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| A2M-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| A2M-20-RE | 20 (40 μL) | 200 μL |  |
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| A2M-20-GO | 20 (40 μL) | 200 μL |  |
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| A2M-20-GR | 20 (40 μL) | 200 μL |  |
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| A2M-20-AQ | 20 (40 μL) | 200 μL |  |
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| A2M-20-DIG | 20 (40 μL) | 200 μL |  |
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| A2M-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Details
Gene Symbol: A2M
Gene Name: Alpha-2-macroglobulin
Chromosome: CHR12: 9220303-9268558
Locus: 12p13.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: A2M FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: A2M-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping