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A2M FISH Probe

The A2M FISH probe is designed to hybridize to the A2M gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
A2M-20-OR  (Standard Design) 20 (40 μL) 200 μL
A2M-20-RE 20 (40 μL) 200 μL
A2M-20-GO 20 (40 μL) 200 μL
A2M-20-GR 20 (40 μL) 200 μL
A2M-20-AQ 20 (40 μL) 200 μL
A2M-20-DIG 20 (40 μL) 200 μL
A2M-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Gene Details

Gene Symbol: A2M

Gene Name: Alpha-2-macroglobulin

Chromosome: CHR12: 9220303-9268558

Locus: 12p13.31

Gene Diseases

The A2M gene has been associated with the following diseases:

Disease Name
2-Hydroxyglutaricaciduria
49,XXXXX Syndrome
Aagenaes Syndrome
Abderhalden-Kaufmann-Lignac Syndrome
Abrikosov's Tumor
Achard Syndrome
Achard-Thiers Syndrome
Acrootoocular Syndrome
Acrorenal Syndrome
Acute Lung Injury
Adenocarcinoid Tumor
Akaba Hayasaka Syndrome
Akesson Syndrome
Aloi Tomasini Isaia Syndrome
Alsing Syndrome
Alzheimer Disease
ALZHEIMER DISEASE 18
ALZHEIMER DISEASE 19
Alzheimer Disease Type 1
Alzheimer Disease Type 2
Alzheimer Disease Type 4
Alzheimer Disease, Familial, 1
Alzheimer Disease, Familial, Type 3
Alzheimer's Disease Without Neurofibrillary Tangles
Ameloonychohypohidrotic Syndrome
Amyloidosis
Androblastoma Of Ovary
Angiolipomatosis, Familial
Ansell Bywaters Elderking Syndrome
Arakawa Syndrome 2
AREDYLD Syndrome
Arima Syndrome
Arthritis
Atrophy
Aughton Syndrome
Ayazi Syndrome
BADS Syndrome
Baetz-Greenwalt Syndrome
Bagatelle Cassidy Syndrome
Bangstad Syndrome
Banki Syndrome
Banti's Syndrome
Basaran Yilmaz Syndrome
Bassoe Syndrome
Bazopoulou Kyrkanidou Syndrome
Beardwell Syndrome
Beemer Ertbruggen Syndrome
Bellini Chiumello Rimoldi Syndrome
Blepharo-cheilo-dontic Syndrome
Blount Disease
Boerhaave Syndrome
Bone Anteversion
Bone Retroversion
Bonneau Syndrome
Boudhina Yedes Khiari Syndrome
Brachioskeletogenital Syndrome
Brachymesophalangy 2 And 5
Breast Cancer, Familial
Broad-Betalipoproteinemia
Brunoni Syndrome
CAHMR Syndrome
Calabro Syndrome
CAMFAK Syndrome
Campomelia Cumming Type
Cancer
CANOMAD Syndrome
Cantalamessa Baldini Ambrosi Syndrome
Carcinoma
Cardiocranial Syndrome
Carrington Syndrome
CATSHL Syndrome
Cerebrooculonasal Syndrome
Chilaiditi Syndrome
CLAPO Syndrome
Cleidorhizomelic Syndrome
COMPLEMENT COMPONENT 2 DEFICIENCY
COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE I
COMPLEMENT FACTOR B DEFICIENCY
Confusion
Contrecoup Injury
Copper Deficiency, Familial Benign
Corneodermatoosseous Syndrome
Coxoauricular Syndrome
Cranioacrofacial Syndrome
Craniofaciofrontodigital Syndrome
Craniomicromelic Syndrome
Crome Syndrome
Cryofibrinogenemia, Familial Primary
Cryptotia, Familial
Curatolo Cilio Pessagno Syndrome
D-glycericacidemia
Daentl Towsend Siegel Syndrome
Daish Hardman Lamont Syndrome
Daneman Davy Mancer Syndrome
Davenport Donlan Syndrome
Death
Degloving Injuries
Dementia
Dermatoosteolysis Kirghizian Type
Devriendt Syndrome
Diabetes Mellitus
Dieterich's Disease
Digitorenocerebral Syndrome
Dimauro Disease
Disease
Drachtman Weinblatt Sitarz Syndrome
Edema
Faciocardiomelic Syndrome
Faciocardiorenal Syndrome
Fairbank Disease
Familial Dermographism
Familial Hyperbeta- And Prebetalipoproteinemia
Familial Streblodactyly
Fibrosis
FLOTCH Syndrome
Flynn Aird Syndrome
Fountain Syndrome
Franceschini Vardeu Guala Syndrome
Freiberg's Disease
Frontoocular Syndrome
Furlong Syndrome
Furukawa Takagi Nakao Syndrome
Gastrocutaneous Syndrome
Gemignani Syndrome
GEMSS Syndrome
Genoa Syndrome
Giacheti Syndrome
Gigantiform Cementoma, Familial
Gollop Coates Syndrome
GOMBO Syndrome
Granddad Syndrome
Grover's Disease
Gurrieri Sammito Bellussi Syndrome
Hadziselimovic Syndrome
Hagemoser Weinstein Bresnick Syndrome
Halal Syndrome
Hallucinations
Hamanishi Ueba Tsuji Syndrome
Hamano Tsukamoto Syndrome
Hapnes Boman Skeie Syndrome
Hardikar Syndrome
Hepatitis
Hepatitis C
Herrmann Syndrome
Hersh Podruch Weisskopk Syndrome
Hooft Disease
Hordnes Engebretsen Knudtson Syndrome
Human Balantidiasis
Hunt's Syndrome
Hyperplasia
Hyperreninemic Hypoaldosteronism, Familial, 2
Hypoadrenocorticism, Familial
Iida Kannari Syndrome
Inflammation
Jagell Holmgren Hofer Syndrome
Kaplowitz Bodurtha Syndrome
Karoshi Death
Kasabach-Merritt Syndrome
Kashani Strom Utley Syndrome
Katsantoni Papadakou Lagoyanni Syndrome
Kennerknecht Sorgo Oberhoffer Syndrome
Kleeblattschaedel Syndrome
Koone Rizzo Elias Syndrome
Kosztolanyi Syndrome
Krasnow Qazi Syndrome
Kuskokwim Disease
Kuzniecky Syndrome
Kyrle Disease
Lachiewicz Sibley Syndrome
Lacrimoauriculodentodigital Syndrome
Lambotte Syndrome
Lelis Syndrome
Lemierre Syndrome
Lung Injury
Lyngstadaas Syndrome
Malignant Teratocarcinosarcoma
Malnutrition
Malouf Syndrome
Manouvrier Syndrome
Marchiafava-Bignami Disease
Marsden Syndrome
Massa Casaer Ceulemans Syndrome
May-Thurner Syndrome
Mehes Syndrome
Melhem Fahl Syndrome
Mengel Konigsmark Syndrome
Meralgia Paraesthetica, Familial
Merlob Grunebaum Reisner Syndrome
Meyenburg-Altherr-Uehlinger Syndrome
Mirizzi Syndrome
Mollica Pavone Antener Syndrome
MOMES Syndrome
Mononen Karnes Senac Syndrome
Morgellons Disease
Multiple Sclerosis
Mutism
Myoclonus
MYOCLONUS, FAMILIAL CORTICAL
Nasodigitoacoustic Syndrome
Nasopharyngeal Carcinoma
Nathalie Syndrome
Necrosis
Neurofaciodigitorenal Syndrome
Nevo Syndrome
Nicolau Syndrome
Nievergelt Syndrome
Nivelon Nivelon Mabille Syndrome
Oculoauriculofrontonasal Syndrome
Oculocerebrocutaneous Syndrome
Oculodental Syndrome Rutherfurd Syndrome
Oculootoradial Syndrome
Oculopalatocerebral Syndrome
Oculopalatoskeletal Syndrome
Oculorenocerebellar Syndrome
Onat Syndrome
Oroticaciduria 1
Oslam Syndrome
Otoonychoperoneal Syndrome
Overweight
Pachydermodactyly, Familial
Pancreatitis
Pancreatitis, Chronic
Paraphilic Disorders
Parkinson Disease
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
PARKINSON DISEASE 17
PARKINSON DISEASE 20, EARLY-ONSET
PARKINSON DISEASE 22, AUTOSOMAL DOMINANT
Parkinson Disease 5
Parkinson Disease 8
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT
Parkinson Disease, Familial, Type 1
PARKINSON DISEASE, LATE-ONSET
Pascual Castroviejo Syndrome
Pashayan Syndrome
Passovoy Factor
Pavone Fiumara Rizzo Syndrome
Pechet Factor Deficiency
Peptide Growth Factors Deficiency
PHACE Association
Pilotto Syndrome
Piriformis Muscle Syndrome
Piussan Lenaerts Mathieu Syndrome
Pneumonia
Podder-Tolmie Syndrome
Polythelia, Familial
Postthrombotic Syndrome
Preeyasombat Varavithya Syndrome
Pregnancy, Cornual
Primary Amyloidosis
Primary Dysautonomias
Propping Zerres Syndrome
Prostate Cancer, Familial
Prostatic Hyperplasia
Pseudoaminopterin Syndrome
Pseudoarylsulfatase A Deficiency
Pseudotrisomy 13 Syndrome
Qazi Markouizos Syndrome
Rambaud Galian Syndrome
Ramer Ladda Syndrome
Reginato Schiapachasse Syndrome
Retinohepatoendocrinologic Syndrome
Rhinitis
Rhinitis, Allergic
RHYNS Syndrome
Ribbing Disease
Richards-Rundle Syndrome
Rombo Syndrome
Rosselli-Gulienetti Syndrome
Rudiger Syndrome
Sakoda Complex
Salcedo Syndrome
Sandifer Syndrome
Satoyoshi Syndrome
Schlegelberger Grote Syndrome
Schofer Beetz Bohl Syndrome
Scholte Syndrome
Schrander-Stumpel Theunissen Hulsmans Syndrome
Sclerosis
Seaver Cassidy Syndrome
Seemanova Lesny Syndrome
Seizures
Sener Syndrome
Shapiro Syndrome
Silengo Lerone Pelizza Syndrome
Sillence Syndrome
Sohval Soffer Syndrome
Steinfeld Syndrome
Summitt Syndrome
SUNCT Syndrome
Susac Syndrome
Syndrome
Syringomas, Multiple
Tabatznik Syndrome
Tatsumi Factor Deficiency
Three M Syndrome 2
Thromboembolism
Tonoki Syndrome
Trichodental Syndrome
Trueb Burg Bottani Syndrome
Tsukahara Syndrome
Tucker Syndrome
Upington Disease
Urinary Incontinence
Velofacioskeletal Syndrome
Verloove-Vanhorick Brubakk Syndrome
Volcke Soekarman Syndrome
Vulvovaginitis, Allergic Seminal
Walbaum Titran Durieux Crepin Syndrome
Waldmann Disease
Warburton Anyane Yeboa Syndrome
Warman Mulliken Hayward Syndrome
Weismann Netter Syndrome
Wyburn Mason's Syndrome
Yusho Disease
Zazam Sheriff Phillips Syndrome
Zechi-Ceide Syndrome
Zlotogora-Ogur Syndrome
Zuska's Disease

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: A2M FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: A2M-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping