5-LOX FISH Probe
The 5-LOX FISH probe is designed to hybridize to the 5-LOX gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ALOX5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-RE | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-GO | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-GR | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-AQ | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-DIG | 20 (40 μL) | 200 μL |  |
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| ALOX5-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Details
Gene Symbol: ALOX5
Gene Name: Arachidonate 5-lipoxygenase
Chromosome: CHR10: 45869628-45941563
Locus: 10q11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 5-LOX FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ALOX5-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping