5'URS Break Apart FISH Probe
Empire Genomics’ 5'URS Break Apart FISH Probe is designed to flank the 5'URS gene and is typically used for detecting 5'URS rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| 5'URSBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-AQOR | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-GOGR | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-GORE | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-GRGO | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-GRRE | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-ORGR | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-REGO | 20 (40 μL) | 200 μL |
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| 5'URSBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This element represents an enhancer that can drive expression of the tyrosinase (TYR) gene in melanocytes. It is located approximately 9 kb upstream of the TYR gene, and is characterized by a melanocyte-specific DNase I hypersensitive site. The orthologous mouse element can function as a locus control region (LCR) that confers high-level and copy number-dependent expression on the tyrosinase gene in melanocytes of transgenic mice. Mutations in the TYR gene are known to result in oculocutaneous albinism (OCA1), but since not all OCA1 cases are associated with mutations in the gene itself, it is thought that mutations in this regulatory element may account for a subset of OCA1 cases for which the molecular basis has yet to be established. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: 5'URS
Gene Name: Tyrosinase 5' Upstream Regulatory Sequence
Locus: 11q14.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 5'URS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: 5'URS-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping