3-HAO FISH Probe
The 3-HAO FISH probe is designed to hybridize to the 3-HAO gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HAAO-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HAAO-20-RE | 20 (40 μL) | 200 μL |  |
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| HAAO-20-GO | 20 (40 μL) | 200 μL |  |
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| HAAO-20-GR | 20 (40 μL) | 200 μL |  |
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| HAAO-20-AQ | 20 (40 μL) | 200 μL |  |
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| HAAO-20-DIG | 20 (40 μL) | 200 μL |  |
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| HAAO-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HAAO
Gene Name: 3-hydroxyanthranilate 3,4-dioxygenase
Chromosome: CHR2: 42994228-43019751
Locus: 2p21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 3-HAO FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HAAO-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping