3'HS1 FISH Probe
The 3'HS1 FISH probe is designed to hybridize to the 3'HS1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HBB-3'HS1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-RE | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-GO | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-GR | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-AQ | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-DIG | 20 (40 μL) | 200 μL |  |
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| HBB-3'HS1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This element represents a DNase I hypersensitive site that is found approximately 20 kb downstream of the beta-globin gene cluster in erythroid cells. It has been shown to function as a scaffold attachment region, and it also has enhancer-blocking activity that is mediated by binding of the CTCF transcription factor. Chromosome conformation capture assays indicate that it is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with the beta-globin locus control region (LCR) and active beta-globin gene promoters. A mutation in this hypersensitive site may be associated with beta-thalassemia intermedia. This hypersensitive site is located in a region that is deleted in some beta-thalassemias, including several hereditary persistence of fetal hemoglobin (HPFH) deletions. [provided by RefSeq, Jul 2015]
Gene Details
Gene Symbol: HBB-3'HS1
Gene Name: Beta-globin 3' Hypersensitive Site 1
Locus: 11p15
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 3'HS1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HBB-3'HS1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping