11-BETA-HSD2 FISH Probe
The 11-BETA-HSD2 FISH probe is designed to hybridize to the 11-BETA-HSD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSD11B2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-RE | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-GO | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-GR | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-AQ | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-DIG | 20 (40 μL) | 200 μL |  |
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| HSD11B2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Gene Details
Gene Symbol: HSD11B2
Gene Name: Hydroxysteroid 11-beta Dehydrogenase 2
Chromosome: CHR16: 67465035-67471454
Locus: 16q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 11-BETA-HSD2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HSD11B2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping