ZNRF3-CRYBB2 Fusion FISH Probe
The ZNRF3-CRYBB2 Fusion FISH Probe is used to confirm a fusion of the ZNRF3 and CRYBB2 genes. The fusion of the ZNRF3 and CRYBB2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNRF3-CRYBB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-RERE | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-REOR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-REGO | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-REGR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-OROR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GORE | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GROR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNRF3-CRYBB2-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYBB2 Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
Gene Name: Crystallin Beta B2
Chromosome: CHR22: 25615611 -25627836
Locus: 22q11.23
ZNRF3 Gene Summary
The Zinc And Ring Finger 3 (ZNRF3) gene is located on chr22 :29279754-29453476 at 22q12.1.
Gene Name: Zinc And Ring Finger 3
Chromosome: CHR22: 29279754 -29453476
Locus: 22q12.1
Gene Diseases
The ZNRF3 CRYBB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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