ZNF704-IMPA1 Fusion FISH Probe
The ZNF704-IMPA1 Fusion FISH Probe is used to confirm a fusion of the ZNF704 and IMPA1 genes. The fusion of the ZNF704 and IMPA1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF704-IMPA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF704-IMPA1-20-AQAQ | 20 (40 μL) | 200 μL |
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IMPA1 Gene Summary
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Gene Name: Inositol Monophosphatase 1
Chromosome: CHR8: 82569150 -82598589
Locus: 8q21.13
ZNF704 Gene Summary
The Zinc Finger Protein 704 (ZNF704) gene is located on chr8 :81540685-81787016 at 8q21.13.
Gene Name: Zinc Finger Protein 704
Chromosome: CHR8: 81540685 -81787016
Locus: 8q21.13
Gene Diseases
The ZNF704 IMPA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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