ZNF675-BRCA1 Fusion FISH Probe
The ZNF675-BRCA1 Fusion FISH Probe is used to confirm a fusion of the ZNF675 and BRCA1 genes. The fusion of the ZNF675 and BRCA1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZNF675-BRCA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ZNF675-BRCA1-20-AQAQ | 20 (40 μL) | 200 μL |
|
BRCA1 Gene Summary
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Gene Name: BRCA1, DNA Repair Associated
Chromosome: CHR17: 41196311 -41277500
Locus: 17q21.31
ZNF675 Gene Summary
The Zinc Finger Protein 675 (ZNF675) gene is located on chr19 :23835707-23870017 at 19p12.
Gene Name: Zinc Finger Protein 675
Chromosome: CHR19: 23835707 -23870017
Locus: 19p12
Gene Diseases
The ZNF675 BRCA1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|