ZNF653-PDE4A Fusion FISH Probe
The ZNF653-PDE4A Fusion FISH Probe is used to confirm a fusion of the ZNF653 and PDE4A genes. The fusion of the ZNF653 and PDE4A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF653-PDE4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF653-PDE4A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE4A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 4A
Chromosome: CHR19: 10527448 -10580307
Locus: 19p13.2
ZNF653 Gene Summary
The Zinc Finger Protein 653 (ZNF653) gene is located on chr19 :11594241-11616738 at 19p13.2.
Gene Name: Zinc Finger Protein 653
Chromosome: CHR19: 11594241 -11616738
Locus: 19p13.2
Gene Diseases
The ZNF653 PDE4A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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