ZNF589-LRRFIP2 Fusion FISH Probe
The ZNF589-LRRFIP2 Fusion FISH Probe is used to confirm a fusion of the ZNF589 and LRRFIP2 genes. The fusion of the ZNF589 and LRRFIP2 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF589-LRRFIP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF589-LRRFIP2-20-AQAQ | 20 (40 μL) | 200 μL |
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LRRFIP2 Gene Summary
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Gene Name: LRR Binding FLII Interacting Protein 2
Chromosome: CHR3: 37094116 -37217851
Locus: 3p22.2
ZNF589 Gene Summary
The Zinc Finger Protein 589 (ZNF589) gene is located on chr3 :48282595-48312479 at 3p21.31.
Gene Name: Zinc Finger Protein 589
Chromosome: CHR3: 48282595 -48312479
Locus: 3p21.31
Gene Diseases
The ZNF589 LRRFIP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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