ZNF516-MBP Fusion FISH Probe
The ZNF516-MBP Fusion FISH Probe is used to confirm a fusion of the ZNF516 and MBP genes. The fusion of the ZNF516 and MBP genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF516-MBP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF516-MBP-20-AQAQ | 20 (40 μL) | 200 μL |
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MBP Gene Summary
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
Gene Name: Myelin Basic Protein
Chromosome: CHR18: 74690788 -74844774
Locus: 18q23
ZNF516 Gene Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Gene Name: Zinc Finger Protein 516
Chromosome: CHR18: 74069636 -74207146
Locus: 18q23
Gene Diseases
The ZNF516 MBP Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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