ZNF461-AKT1 Fusion FISH Probe
The ZNF461-AKT1 Fusion FISH Probe is used to confirm a fusion of the ZNF461 and AKT1 genes. The fusion of the ZNF461 and AKT1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF461-AKT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF461-AKT1-20-AQAQ | 20 (40 μL) | 200 μL |
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AKT1 Gene Summary
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: AKT Serine/threonine Kinase 1
Chromosome: CHR14: 105235686 -105262080
Locus: 14q32.33
ZNF461 Gene Summary
The Zinc Finger Protein 461 (ZNF461) gene is located on chr19 :37128282-37157739 at 19q13.12.
Gene Name: Zinc Finger Protein 461
Chromosome: CHR19: 37128282 -37157739
Locus: 19q13.12
Gene Diseases
The ZNF461 AKT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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