ZNF433-CACNA1A Fusion FISH Probe
The ZNF433-CACNA1A Fusion FISH Probe is used to confirm a fusion of the ZNF433 and CACNA1A genes. The fusion of the ZNF433 and CACNA1A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF433-CACNA1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF433-CACNA1A-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1A Gene Summary
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 A
Chromosome: CHR19: 13317255 -13617274
Locus: 19p13.13
ZNF433 Gene Summary
The Zinc Finger Protein 433 (ZNF433) gene is located on chr19 :12125531-12146525 at 19p13.2.
Gene Name: Zinc Finger Protein 433
Chromosome: CHR19: 12125531 -12146525
Locus: 19p13.2
Gene Diseases
The ZNF433 CACNA1A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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