ZNF423-NOD2 Fusion FISH Probe
The ZNF423-NOD2 Fusion FISH Probe is used to confirm a fusion of the ZNF423 and NOD2 genes. The fusion of the ZNF423 and NOD2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF423-NOD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF423-NOD2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZNF423 Gene Summary
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Gene Name: Zinc Finger Protein 423
Chromosome: CHR16: 49524520 -49860918
Locus: 16q12.1
NOD2 Gene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Name: Nucleotide Binding Oligomerization Domain Containing 2
Chromosome: CHR16: 50731049 -50766987
Locus: 16q12.1
Gene Diseases
The ZNF423 NOD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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